890 research outputs found

    Intraventricular Thrombi with Systemic Embolization: Two Clinical Cases

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    A formação de trombos intraventriculares é um complicação frequente nos doentes com miocardiopatia dilatada e enfarte agudo do miocárdio, sendo o risco de embolização sistémica muito variável em função da patologia subjacente e características subjacentes dos trombos. Os autores descrevem dois casos clínicos relativos a dois doentes internados no mesmo dia com trombos intraventriculares, volumosos, protuberantes e muito móveis, no contexto de miocardiopatia dilatada e enfarte agudo do miocárdio, que embolizaram para os membros inferiores. Salientam a importância da ecocardiografia no diagnóstico, caracterização morfológica inicial e controlo evolutivo dos trombos intraventriculares, aspectos fundamentais na avaliação do risco embólico. Na ausência de recomendações específicas quanto às opções terapêuticas – anticoagulação, trombólise ou remoção cirúrgica, os autores sublinham a necessidade de avaliação individualizada, «caso a caso», tendo em conta o risco embólico, hemorrágico, e cirúrgico

    Weighing-in-motion wireless system for sustainable railway transport

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    Railway transport is well known as one of the safest and most energy-efficient transport modes, thus favoring its strengthening as part of a sustainable transport system. Yet, the track service life and the quality of the ride on a railway are dependent upon different factors, which can be assessed by a diverse set of technology based systems. In this context, this paper presents the EVO4Rail project that seeks to design, develop and implement a wireless monitoring system for weighing-in-motion and detecting faulty wheels in railway vehicles, positively impacting railway operation, maintenance and management, ultimately aiming at a sustainable rail transport.info:eu-repo/semantics/publishedVersio

    Concomitant pulmonary embolism and aortic dissection: approach to anticoagulation

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    Os autores descrevem um caso de uma doente admitida após episódio pré-sincopal associado a precordialgia e cujo ecocardiograma sumário feito no Servic¸o de Urgência demonstrou alterac¸ões compatíveis com tromboembolismo pulmonar, tendo a doente sido submetida a terapêutica fibrinolítica, após episódio de paragem cardiorrespiratória. Na angiotomografia de tórax feita posteriormente para confirmac¸ão diagnóstica demonstra-se a presenc¸a não só de trombos no nível da artéria pulmonar, mas também de dissec¸ão da aorta Stanford B, tendo-se optado pela manutenc¸ão de anticoagulac¸ão terapêutica e a doente evoluído de forma favorável.The authors describe a case of a patient admitted with a pre-syncopal episode and precordial discomfort, and whose cardiac ultrasound performed in the Emergency Room was suggestive of Pulmonary Embolism. The patient was submitted to fibrinolytic therapy after cardiac arrest. The computerized tomography done after this episode not only confirmed the presence of pulmonary embolism but had also shown a Stanford Type B Aortic Dissection. The option was to maintain the therapeutic anticoagulation, having the patient evolved favourably.info:eu-repo/semantics/publishedVersio

    Model for deriving benthic irradiance in the Great Barrier Reef from MODIS satellite imagery

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    We demonstrate a simple, spectrally resolved ocean color remote sensing model to estimate benthic photosynthetically active radiation (bPAR) for the waters of the Great Barrier Reef (GBR), Australia. For coastal marine environments and coral reefs, the underwater light field is critical to ecosystem health, but data on bPAR rarely exist at ecologically relevant spatio-temporal scales. The bPAR model presented here is based on Lambert-Beer’s Law and uses: (i) sea surface values of the downwelling solar irradiance, Es(λ); (ii) high-resolution seafloor bathymetry data; and (iii) spectral estimates of the diffuse attenuation coefficient, Kd(λ), calculated from GBR-specific spectral inherent optical properties (IOPs). We first derive estimates of instantaneous bPAR. Assuming clear skies, these instantaneous values were then used to obtain daily integrated benthic PAR values. Matchup comparisons between concurrent satellite-derived bPAR and in situ values recorded at four optically varying test sites indicated strong agreement, small bias, and low mean absolute error. Overall, the matchup results suggest that our benthic irradiance model was robust to spatial variation in optical properties, typical of complex shallow coastal waters such as the GBR. We demonstrated the bPAR model for a small test region in the central GBR, with the results revealing strong patterns of temporal variability. The model will provide baseline datasets to assess changes in bPAR and its external drivers and may form the basis for a future GBR water-quality index. This model may also be applicable to other coastal waters for which spectral IOP and high-resolution bathymetry data exist

    The relationship between sedentary behavior and dry eye disease

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    Purpose: Sedentary behavior (SB) has been linked with low-grade systemic inflammation, which could play a role in the development of dry eye disease (DED). This cross-sectional study aims to investigate the association between SB and DED. Methods: We assessed 48,418 participants from the population-based Lifelines cohort (58% female, 18–96 years). Women's Health Study (WHS)-defined DED was the primary outcome. SB was assessed using the Marshall Sitting Questionnaire. The relationship between DED and SB was analyzed using logistic regressions, corrected for age, sex, BMI, smoking status, demographics, and 48 comorbidities. Any potential modifying effect of physical activity (PA) was also assessed, and the analyses were repeated excluding the most computer-intensive domains, investigating SB independent from screen exposure. Results: WHS-defined DED was present in 9.1% of participants. Greater SB was associated with an increased risk of DED (odds ratio (OR) 1.015 per hour/day, 95%CI 1.005–1.024, P = 0.004). The association between SB and DED was only significant for those with less than WHO-recommended PA (OR 1.022, 95%CI 1.002–1.042, P = 0.027), and not in participants meeting WHO's recommendation (OR 1.011, 95%CI 0.999–1.023, P = 0.076). Lastly, when excluding computer-related sitting, the relationship between SB and DED was attenuated, and no longer significant (OR 1.009, 95%CI 0.996–1.023, P = 0.19). Conclusions: Greater sedentary time was tied to an increased risk of DED, especially for those with lower PA levels than WHO recommendations. However, as there was no significant association when computer-intensive sitting time was excluded, screen use could explain the observed relationship and should be noted as a possible key confounder.</p

    The relationship between dry eye and sleep quality

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    Purpose: Sleep is an important determinant of health and quality of life. This study aimed to clarify the association between dry eye and sleep quality using a large population-based cohort. Methods: 71,761 participants (19-94 yrs, 59.4% female) from the Lifelines cohort in the Netherlands were assessed for dry eye using the Women's Health Study Dry Eye Questionnaire. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). Logistic regression was used to examine the relationship between poor sleep quality (PSQI score > 5) and dry eye, while correcting for age, sex, BMI, education, income, and 51 possible confounding comorbidities, including autoimmune diseases and psychiatric disorders. Results: Overall, 8.9% of participants had dry eye. Of these, 36.4% had poor sleep quality compared to 24.8% of controls (OR 1.52 (95%CI 1.44-1.60), P < 0.0001, corrected for age and sex). After correcting for all comorbidities, dry eye was still associated with poor sleep (OR 1.20 (95%CI 1.11-1.28), P < 0.0001). This relationship was seen across all ages and sexes. Patients with dry eye scored worse on all subcomponents of the PSQI. Almost one-in-two (44.9%) persons with dry eye symptoms "often" or "constantly" had poor sleep quality. This proportion was similar to participants with sleep apnea and osteoarthritis. Additionally, increasing symptom frequency was tied to increased prevalence of poor sleep quality. Conclusions: All components of sleep quality were significantly reduced in participants with dry eye, even after correcting for comorbidities. These results indicate the substantial impact of dry eye on patients' lives, especially for those with frequent symptoms

    The work-related burden of dry eye

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    Purpose: To investigate the relationship between dry eye disease (DED) and work functioning, unemployment, absenteeism, and worry about job loss. Methods: DED and unemployment, absenteeism, and ‘worry about job loss’ were assessed in 71,067 subjects (18–65 years, 60% female) from the Dutch population-based Lifelines cohort using the Women's Health study questionnaire and single-item questions, respectively. Work functioning was assessed in 32,475 participants using the Work role functioning questionnaire 2.0. The relationships between DED and work measures were assessed with logistic regression models, corrected for age, sex, BMI, income, educational level, smoking, and 48 comorbidities. Results: 8.3% of participants had DED and had more impaired work functioning compared to those without DED (49.2% vs 41.1%, OR 1.21, 95% CI 1.10–1.32, corrected for demographics, smoking and 48 comorbidities). DED carried a similar risk of impaired work functioning as rheumatoid arthritis. For participants with highly symptomatic dry eye impaired work functioning was even higher (59.1%) and similar to that of depression. The impaired work functioning seen with increasing symptoms were greater in undiagnosed subjects versus diagnosed subjects (P = 0.03). After correction for comorbidities, DED remained tied to absenteeism and increased worry about job loss, but not unemployment. Conclusion: DED was linked to impaired work functioning and absence, but not unemployment. DEDs impact on work functioning is comparable to that of other severe chronic disorders, and undiagnosed subjects may be more affected. This highlights the importance of recognizing DED as a severe disorder and of screening for dry eye in the workplace to aid with diagnosis and treatment.</p

    Two-Photon Doppler cooling of alkaline-earth-metal and ytterbium atoms

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    A new possibility of laser cooling of alkaline-earth-metal and Ytterbium atoms using a two-photon transition is analyzed. We consider a 1S0^{1}S_{0} - 1S0^{1}S_{0} transition, with excitation in near resonance with the 1P1^{1}P_{1} level. This greatly increases the two-photon transition rate, allowing an effective transfer of momentum. The experimental implementation of this technique is discussed and we show that for Calcium, for example, two-photon cooling can be used to achieve a Doppler limit of 123 microKelvin. The efficiency of this cooling scheme and the main loss mechanisms are analyzed.Comment: 7 pages, 5 figure
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